ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myeloid leukemia (CML) is resulted from t (9; 22) (q34; q11) chromosome translocation, which produces a bcr-abl fusion gene on the Philadelphia (Ph) chromosome, encoding p210BCR-ABL fusion protein with aberrant tyrosine kinase activity [1, 2].