BRCA1 and breast carcinoma: When the three groups were considered separately, the average age at diagnosis of breast cancer in the family, in the BRCA1-pathogenic, BRCA1-VUS and BRCA1-WT groups were respectively 44.1; 41.2 and 42.5 years (SD = 5.7, 9.7 and 10.7 years, respectively).