Besides, 73.9% of the families in the BRCA1-pathogenic group had 3 or more cases of breast cancer in their families, while 63.6% and 64.3% of the families with VUS at BRCA1 gene and BRCA1-WT respectively, reported up to two cases of breast cancer in the family (p = 0.007). The gene discussed is BRCA1; the disease is breast cancer.