Although the correlation between promoter hypermethylation of BRCA1 gene with transcriptional inactivation has been reported in several studies [19, 20], as well as the association of the methylation level with clinical stage [20], histologic grade [20], triple negative phenotype [20, 21], and ancestry [21], there is little evidence on the correlation between the BRCA1 methylation status and hereditary breast cancer. The gene discussed is BRCA1; the disease is breast cancer.