When HF were pre-treated with latrunculin-A for 12 h and then subjected to Ver or Etop for another 12 h, the living cell number was reduced from ~300 to ~50 when compared to Ver or Etop treatment alone (Figure 7C–7D), suggesting latrunculin-A-induced disruption of P-glycoprotein/MRP1-actin association abolished the drug resistance in HF. The gene discussed is ABCC1; the disease is hydrops fetalis.