Therefore, multiple treatments are encouraged to strengthen the management of metastatic brain lesions in EGFR mutation-positive NSCLC patients, such as increase of EGFR-TKI doses, administration of new-generation EGFR-TKIs to increase the drug concentration in the cerebrospinal fluid, and optimized combination of EGFR-TKI and whole brain radiotherapy, in order to extend OS in EGFR mutant NSCLC patients with brain metastasis. This evidence concerns the gene EGFR and non-small cell lung carcinoma.