In the current study, no significant differences were observed in the ORR or DCR between stage IV NSCLC patients harboring EGFR 19del mutation and L858R mutation at exon 21, and univariate analysis showed a clear-cut effect of the EGFR mutation type on PFS (P = 0.003); however, the type of EGFR mutation was found to have no significant effect on OS (P = 0.158), which may be associated with the use of systemic chemotherapy in the study subjects. Here, EGFR is linked to non-small cell lung carcinoma.