The mechanism remains unknown, but may be that, firstly, RDW correlated with IL-6, tumor necrosis factor-alpha, hepcidin and other circulating cytokines that can affect the tumor cell biological behavior [34, 35]; secondly, RDW may present the constitutive level of IGF-1 signaling, the critical factor accountable for metabolic aging and longevity [12]; thirdly, RDW showed the nutritional status of patients including iron, folate, and vitamin B12 [22], and lower RDW was associated with poor nutritional status which was another hallmark of cancer [36]. The gene discussed is TNF; the disease is cancer.