Further understanding of molecular biology of IBC focusing on the tumor microenvironment and immunity may help explain the different clinical behaviors of IBC and non-IBC e.g. the role of mesenchymal transitional cells in promoting E-cadherin (pivotal to IBC metastasis) expression in IBC cell models and metastases in xenografts [50, 75]. The gene discussed is CDH1; the disease is inflammatory breast carcinoma.