PSEN1 and familial Alzheimer disease: Four iPSC lines were generated from skin fibroblasts of two FAD patients with PSEN1 mutations, including one line from a patient bearing a mutation of three-nucleoside-deletion (heterozygous S169del, termed A16-iPSC-1) and three lines from another patient carrying a missense mutation (heterozygous A246E, termed A15-iPSC-2, -3, and -4, respectively) (Supplementary Figure 1a and 1b).