The reduction of ALDH+ cells, a widely accepted parameter reflecting CSCs, in RPMI8226, MM.1S and LP1 cell lines treated with GSK126 indicated a promising application of GSK126 in treatment of MM, as the relapse of MM may be caused by the drug-resistant and self-renewable myeloma stem cells [28, 44, 45]. Here, LDHA is linked to Miyoshi myopathy.