EGF and neoplasm: Importantly, our data indicated that 2-DG treatment had no obvious inhibitory effects on the in situ tumor growth (Supplementary Figure 4B), but dramatically reduced the degree and incidence of EGF-facilitated cervical LN metastases of SCC-1 cells (30% versus 70%) even though there was no significant statistic difference (Figure 6C, Table 1 ; p=0.101).