The abundance of EGF together with the overexpression of EGFR observed in diverse types of cancers, including head and neck cancer [7, 22, 34], lead to aberrant activation of the downstream signaling pathways that facilitate EMT process [40, 41], which subsequently renders cancer cells with plastic properties and increased invasive and metastatic capabilities [22, 34, 41]. Here, EGFR is linked to cancer.