Therefore, it is likely that fibronectin-integrin interactions promote development of mesenchymal phenotypes in prostate cancer cells with no or low CD82 levels, but reinforce an epithelial phenotype in cells with high CD82 levels, implicating differential effects of fibronectin adhesion on the epithelial/mesenchymal state of prostate cancer cells depending on CD82 expression levels. This evidence concerns the gene FN1 and prostate carcinoma.