We examined the expression levels of CD82, E-cadherin, and mesenchymal proteins including Snail, α-smooth muscle actin (α-SMA), and vimentin in human prostate cancer tissues from patients through immunofluorescence staining of tissue microarray sections comprising 90 prostate adenocarcinomas with different malignant stages and 12 non-neoplastic prostate tissue samples. The gene discussed is CD82; the disease is prostate cancer.