CD4 and myeloid sarcoma: Although there are many ways to induce antigen‐specific tolerance, a consistently robust method has been achieved by intravenous antigen delivery following transient T‐cell deletion.4, 15 This combination, and not the individual treatments, eliminates relapsing EAE in animals with established disease.4 Similarly, depletion of CD4 T cells6, 7 and depletion of intravenous oligodendrocyte‐directed antigens16, 17 have been tried and so far failed to eliminate relapses in MS, despite some efficacy.