Strikingly, overexpression of GATA3 and FOXA1 in the presence of PPARɣ agonist modulated the expression of several transcription factors that are differentially expressed between luminal and basal human bladder cancers, including ELF3, SNAI1, and SNAI2 (both implicated in epithelial to mesenchymal transition51) and TFAP2A52 among others (Fig. 7, see supplemental protocol). This evidence concerns the gene SNAI2 and urinary bladder cancer.