Accordingly, our integrated analysis of CCLE and TCGA data provided us a unique opportunity to design experiments to directly test the individual and combined contribution of GATA3, FOXA1, and PPARɣ to the regulation of genes associated with the luminal molecular subtype of bladder cancer, as well as the establishment of the luminal molecular signature in bladder cancer cells. The gene discussed is FOXA1; the disease is urinary bladder cancer.