ELISA results showed upregulation of pro-inflammatory cytokines IL-17 [Fig. 6A], IFN-γ [Fig. 6B], TNF-α [Fig. 6C], IL-6 [Fig. 6D], and IL-1β [Fig. 6E] in EAE mice, while administration of hPDLSCs-CM and EMVs derived from MS patients and donors suppressed the activation of these cytokines in EAE mice. This evidence concerns the gene TNF and myeloid sarcoma.