Immunohistochemistry results showed prominent positive staining for pro-inflammatory CD4 [Fig. 5H] in EAE mice, while EAE mice administered with hPDLSCs-CM or hPDLSCs-EMVs derived from MS patients [Fig. 5I and J, respectively] and donors [Fig. 5K and L, respectively] showed negative staining. Here, CD4 is linked to myeloid sarcoma.