Many reports indicate that the oncogene KRAS has an important role not only in cellular transformation and metabolic reprograming during tumorigenesis but also in chemotherapy for colorectal cancer, considering that mutant KRAS transduces oncogenic signaling and is the most reliable predictor for cancer response to anti-EGFR monoclonal antibodies11, 12, 13. Here, EGFR is linked to colorectal cancer.