Overall, the CSF IL-10 level was correlated with increased CSF protein (r 0.587, P = 0.004), the numbers of lesions (r 0.521, P = 0.013)and Prognostic Scoring System for PCNSL(r 0.625, P = 0.002), but the level was not related to the CSF pressure or serum lactate dehydrogenase (sLDH) in PCNSL patients (Table 3). The gene discussed is IL10; the disease is primary central nervous system lymphoma.