The expression level of miR-182-5p showed strong positive correlations with SLE parameters of miR-96-5p, spleen weight, lymph node weight, spleen weight/body weight, glomerular C3 deposition, percentage of CD138+ cells, percentage of T-bet+ of CD4+ CD25+ cells, and Th1/Th2. The gene discussed is SDC1; the disease is systemic lupus erythematosus.