Jouan-Lanhouet et al.69 examined the effect of necrostatin-1 (125 μg) administration 15 min before on ConA (20 mg/kg, retro-orbital injection) induced hepatitis on liver damage using female C57BL6 mice and reported a decrease of about 50% in ALT and histologic injury versus PBS pre-treatment. This evidence concerns the gene GPT and Hepatitis.