Wang and colleagues used the Gao-binge model of alcohol feeding and reported an increased expression of RIPK3 using a (polyclonal RIPK3 antibody) with alcohol and protection from global RIPK3 deletion (ALT and steatosis) but no difference in hepatitis and neutrophil infiltration in the RIPK3−/− mice. The gene discussed is RIPK3; the disease is hepatitis A virus infection.