However, this does not seem to be the case with ConA as the lectin alone can result in hepatitis and cell death without the need for transcriptional or translational inhibition.57 In addition to TNF, other major cytokines such as IFN-γ, IL4, IL6 and other DR pathways (Fas, TRAIL) have also been implicated in ConA hepatotoxicity, although to a lesser extent than TNF.60–65 The ConA model is very complex. Here, TNF is linked to Hepatitis.