Two groups have investigated the role of RIPK3 in liver injury, using the methionine choline-deficient model, which is used as a NASH model.87,88 Gautheron et al. 88 demonstrate an increase in RIPK3 expression using IHC and western blotting (polyclonal antibody). Here, RIPK3 is linked to metabolic dysfunction-associated steatohepatitis.