AHRR and laryngotracheoesophageal cleft: Our previous investigations focused on these top-ranked loci have demonstrated that F2RL3 methylation is a strong predictor for both LC incidence and mortality [15], and smoking-induced hypomethylation at cg05575921 in AHRR and cg06126421 in 6p21.33 are strongly associated with increased risk of overall cancer death [16].