RNA interfere technique (RNAi) was successfully used to target and disable a group of crucial genes for HNSCC treatment [109, 110], including EGFR [111], EpCAM [112], MET receptor [113], Cyclin D1, NF-κB, p65, VEGFR, telomerase reverse transcriptase and p63 [111]. Here, EGFR is linked to head and neck squamous cell carcinoma.