NLRP3 and gout: Overproduction of IL-1β resulted from dysregulated NLRP3 inflammasome activation is proved to be associated with type 2 diabetes, rheumatoid arthritis, gout, atherosclerosis, and Alzheimer's disease, more importantly, emerging evidences suggest the pivotal role of NLRP3 inflammasome in mediating liver inflammation and fibrosis [24-26].