The FoxO family of transcription factors (FoxOs), FOXO1 (FKHR), FOXO3 (FKHRL1 or FOXO3a), FOXO4 (AFX) and FOXO6, integrate multiple cellular signals and translate various environmental stimuli into dynamic patterns of gene expression that influence a broad range of physiological and pathological processes, including cancer and aging [12]. This evidence concerns the gene FOXO4 and cancer.