Interestingly the overexpression of the ubiquitin E3 ligase gene (CUL4A), found to have differential ASE in our ischemia model, has been found to suppress apoptosis and DNA damage in experimental pheochromocytoma model of ischemia-reperfusion [29]. The gene discussed is MUL1; the disease is hereditary pheochromocytoma-paraganglioma.