For the informative features with p values of t-test below 0.09 (0.09 is the selected p value threshold for type 1 diabetes using the method described in the “Methods” section), we find that more features associated with open chromatin or TF binding show enrichment around risk variants, while more features associated with histone modifications show depletion around risk variants (Fig. 2d). The gene discussed is TF; the disease is type 1 diabetes mellitus.