Additionally, IL-10 has been shown to inhibit production of IFN-γ by Th1 cells, of TNF-α by macrophages, and of cytokines by monocytes, and proliferation of T cells and cytokine responses, which emphasizes the role of IL-10 function in the immune shift toward a Th2 response and immunosuppression after stroke [33]. This evidence concerns the gene IL10 and Stroke.