In initial experiments, we assessed the expression of C-type lectin Mincle in WT mice infected with focal pneumonia inducing serotype 19F S. pneumoniae. As shown in Fig 1A, Mincle gene expression was found to peak in lung tissue of mice at 24 h post S. pneumoniae challenge, with a strong decline towards 72 h post-infection. The gene discussed is CLEC4E; the disease is infection.