CLEC4E and infection: As shown in S5 Fig, we did not observe any significant differences in either numbers of resident AM (S5A Fig), or newly recruited exudate macrophages (S5B Fig), or alveolar recruited neutrophils in BAL fluids of WT versus Mincle KO mice until 72 h post-infection, except that just on day 4 post-challenge, Mincle KO mice had slightly but significantly increased neutrophil counts in their BAL fluids relative to S. pneumoniae infected WT mice (S5C Fig).