CLEC4E and bronchopneumonia: After type 19F S. pneumoniae infection, we observed purulent, mostly focal bronchopneumonia with accompanying organizing pneumonia in lung tissue sections of Mincle KO mice on day 3 and even more so on day 7 post-infection, which was significantly less pronounced in WT mice (Fig 4F and 4G), collectively demonstrating that Mincle is particularly important to lung protective immunity against focal pneumonia-causing S. pneumoniae in mice.