CD169+ macrophages have not previously been examined for involvement in control of P. chabaudi infection, but a recent study demonstrated that systemic depletion of CD169+ macrophages increased tissue sequestration of parasites, morbidity, and mortality in a model of experimental cerebral malaria (ECM) employing the pathogen P. berghei ANKA in ECM-resistant Balb/C mice. This evidence concerns the gene SIGLEC1 and cerebral malaria.