SIGLEC1 and parasitic infectious disease: Mice depleted of CD169+ cells 12 d.p.i. developed significantly higher parasitemia (Fig 6D), weight loss (Fig 6E), and mortality (Fig 6F) relative to controls treated with a catalytically inactive point mutant (DT*Glu), indicating a role for these macrophages in control of P. chabaudi. To exclude off-target effects of DT treatment, we examined frequencies of additional myeloid subsets.