SIGLEC1 and parasitic infectious disease: In addition to MMMs and SCSMs, DT treatment in CD169+/DTR mice also resulted in depletion of bone marrow macrophages, which express CD169 [69] (Fig 5G); however, using a separate transgenic mouse model, in which the DT receptor is expressed under control of the Lyz2 promoter (Lyz2Cre/Cre; Rosa26::STOPfl/fl::DTR) [70], we found that depletion of bone marrow macrophages, as confirmed by flow cytometry (Fig 5H), in itself had no effect on parasitemia (Fig 5I).