We identified ZNSCAN1 among a set of genes that are mutually exclusively mutated in lung adenocarcinoma and are all involved in the RTK/RAS/RAF pathway, including EGFR, BRAF, KRAS, MET, and NF1. This suggests that ZKSCAN1, like the other genes in this pathway, has an important role in lung carcinogenesis. This evidence concerns the gene ZKSCAN1 and lung adenocarcinoma.