FLVCR1 and Sensory neuropathy: To substantiate the role of FLVCR1 in sensory neuropathies additional index cases and trios were subjected to next-generation sequencing using a gene panel consisting of 70 genes implicated in HSAN and similar syndromes, including FLVCR1. Amongst 165 index cases, we identified a second case with early-onset sensory neuropathy (patient 2) and compound heterozygous mutations c.661C>T; p.(Pro221Ser) and c.1324dup; p.(Tyr442Leufs*7) in FLVCR1 (Fig 1B and 1D).