Comparing IBC to non-IBC, the only different recurrent focal SCNA was the amplification of 11q13.5 containing PAK1 in IBC; PAK1 is an oncogene that activates MAPK and MET signalling and regulates cell motility, and previous reports have associated IBC with MAPK hyperactivation [50,51]. Here, PAK1 is linked to inflammatory breast carcinoma.