Logistic models that regress IS status on age acceleration (model 1), adjusted by sex (model 2), adjusted by sex, diabetes mellitus, hypertension, atrial fibrillation, and smoking habit (model 3) and adjusted by sex, diabetes mellitus, hypertension, atrial fibrillation, smoking habit and blood cell count associated to Hannum (NK, monocytes, CD4+ T cells, naïve CD8 T cells and CD8+CD28-CD45RA-) and Horvath (NK, monocytes, CD8+ T cells, naïve CD8 and CD4 T) (model 4). The gene discussed is CD28; the disease is hypertensive disorder.