Mutations in the human BUB1B gene (encoding BUBR1 protein) are associated with mosaic variegated aneuploidy (MVA) syndrome [10], a childhood syndrome characterized by reduced levels of BubR1 expression and various progeroid features including a short lifespan, short stature, and facial dysmprphisms, cataracts, and cancer predisposition [11, 12]. The gene discussed is BUB1B; the disease is cataract.