The estrogen-regulated pattern of eNOS-containing complexes present along the regulatory genomic regions of a subgroup of cancer-associated lncRNAs, specifically HOTAIR and MALAT1, prompted us to investigate them as potential targets as well as effectors of the ER signaling in a non-canonical microenvironment such as that of prostate cancer. This evidence concerns the gene MALAT1 and Familial prostate cancer.