Analysis of these lncRNAs by ChIP-Seq in prostate cancer cells showed that the eNOS-peaks were present on the HOTAIR and ANRIL promoter region before and after stimulation with 17β-estradiol (E2) and on the MALAT1 promoter region exclusively upon E2 treatment (Fig. 1a,b and Supplementary Fig. S1). Here, NOS3 is linked to Familial prostate cancer.