The recruitment of CAF is induced by diverse cytokines that secreted by cancer cells and other stromal cells, including transforming growth factor-β (TGFβ), epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and fibroblast growth factor 2 (FGF2), CXCL12 and so on30. This evidence concerns the gene FGF2 and cancer.