We found 21 genes that are significantly and frequently upregulated in two pancreatic cancer gene expression datasets (top 1% ranked genes, fold change >2; P < 0.0001): ADAM8, AHNAK2, BUB1, C16orf75, CCNB1, CDH3, CLTB, ECT2, FOXL1, KIAA1199, KIF14, KIF4A, MYEOV, NMU, P4HA1, SDR16C5, SERPINB5, SLC6A14, TPX2, TTLL12, and WFDC2 (Supplementary Data 1). This evidence concerns the gene ADAM8 and familial pancreatic carcinoma.