TUG1 and central nervous system cancer: Importantly, attenuation of the Notch-TUG1 axis by siRNA or γ-secretase in regulating self-renewal of glioma cells was efficiently rescued by TUG1 exon 1 transcript where the miR-145-binding site locates indicating that there is a pivotal role for the exon 1 and miR-145 interaction in maintenance of stemness properties.