Hence, SMARCB1 plays the role of a classic tumour suppressor gene in rhabdoid tumours according to the Knudson two-hit model (Versteege et al. 1998; Biegel et al. 1999; Uno et al. 2002; Jackson et al. 2009; Kordes et al. 2010; Bourdeaut et al. 2011). The gene discussed is SMARCB1; the disease is neoplasm.