SMARCB1 and schwannoma: In the schwannomas, but not the blood cells of this patient, Castellanos et al. detected a large deletion encompassing not only the NF2 gene but also large parts of chromosome 22 telomeric to NF2. Neither SMARCB1 nor LZTR1 was included within the bounds of this deletion, since these genes are located centromeric to NF2. Importantly, the deletion exhibited the same breakpoint in both schwannomas from this patient, indicating that the deletion represented the first-hit mutation.