Since researches on the biochemistry of PSA, have a high influence on the potential for cooperation between the discovery and management of prostate cancer, and considering the high prevalence of metabolic syndrome and risk of metabolic syndrome impact on the PSA, as well as the lack of similar studies in Iran and reference books, we decided to study the impact of BMI, blood sugar and blood lipid profile on serum PSA level. Here, KLK3 is linked to prostate carcinoma.