Thus, considering the prevalence of prostate cancer and the importance of PSA in detecting prostate cancer, several studies have been examined, in relation to PSA level in different people and its relation to other factors that the most important of them was the relationship between PSA and a number of metabolic syndrome components such as high blood sugar, high blood lipids and obesity (3-11). The gene discussed is KLK3; the disease is Familial prostate cancer.