It has been shown that the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) is modified by the nitrosative stress and contains nitrotyrosine in angiotensin II-induced hypertensive rat kidney, which may facilitate the oxidative/nitrosative stress and renal injury (Xu et al., 2006). The gene discussed is SOD2; the disease is urogenital neoplasm.