CSF1 and myocardial infarction: Paradoxically, immunosuppressive therapy with methylprednisolone resulted in increased catastrophic mortality due to cardiac rupture.6, 7 Indeed, several experimental data show that macrophage colony‐stimulating factor (M‐CSF) treatment increases macrophage infiltration post‐MI, resulting in improved cardiac function and accelerated infarct repair, while macrophage depletion using clodronate‐containing liposomes impaired wound healing in a murine model.8, 9, 10 Therefore, controlled inflammation and immune response are prerequisites for adequate cardiac healing after MI.