It has been demonstrated that insufficient recruitment of Treg cells results in exacerbating ventricular remodeling and Treg cells attenuate cardiac remodeling after MI.35, 57 In the present study, Foxp3+ Treg cells and the expression of Foxp3 mRNA were both increased in CD4+ T cells co‐cultured with tDCs, and both a significant suppression of Th1 and Th17 cells immunity and marked expansion of Treg cells were observed in mice adoptive transferred with such DCs. Here, CD4 is linked to myocardial infarction.