In the present study, we observed that administration of recombinant human IL‐37 in mice suppressed infiltration of inflammatory cells (including neutrophils, macrophages, and T lymphocytes) and proinflammatory cytokines (including IL‐6, IL‐1β, and TNF‐α) in the post‐MI hearts, thus ameliorating ventricular remodeling. Here, TNF is linked to myocardial infarction.