DDX41 and infection: For example, anti-V1V2 IgG Abs capable of mediating Ab-dependent cellular cytotoxicity (ADCC) were induced by the candidate HIV-1 vaccine regimen in the RV144 trial (Pollara et al., 2014), which at relatively high levels correlated with reduced infection risk (Haynes et al., 2012, Yates et al., 2014).