CALR and cancer: For example, secreted and membrane-associated forms of Calreticulin are important in the host immune response to cancer with respect to activation of T cells, peptide loading with tumour antigens and in the phagocytosis of tumour cells by dendritic cells, which has been used to design chemotherapeutic approaches (Chaput et al., 2007, Feng et al., 2015, Gardai et al., 2005, Obeid et al., 2007, Wemeau et al., 2010).