Initial workup of the patient for secondary causes of dystonia was unrevealing and included complete blood count (CBC) with peripheral smear (no acanthocytes seen), normal sedimentation rate, vitamin B12, methylmalonic acid, electrolytes, ammonia, ceruloplasmin, copper, liver function tests, thyroid-stimulating hormone (TSH), paraneoplastic profile, tests of connective tissue disorders, sera rapid plasma reagin (RPR), negative anti-thyroid peroxidase (TPO) antibodies and tissue transglutaminase antibodies. The gene discussed is TPO; the disease is connective tissue disorder.