NOTCH1 and intrahepatic cholangiocarcinoma: Mounting evidence underlines the critical role of Notch signalling in ICC pathogenesis.10, 11 For instance, Notch receptors are upregulated in human ICC specimens,35 and high expression of Notch1 is associated with invasive ICC growth.36 In addition, treatment of human ICC cells with a γ-secretase inhibitor was found to effectively inhibit ICC cell growth and induce apoptosis in vitro.