AKT1 and intrahepatic cholangiocarcinoma: In a recent study from our lab, we showed that anti-Notch2 and anti-Jag1 antibodies were able to inhibit the growth of ICC-like lesions in AKT/Ras mice.46 The study suggests that anti-Notch2 and anti-Jag1 antibodies might represent novel and effective treatment for ICC.