In particular, patients with high miR-221 intra-tumor levels and wt TP53 might benefit of clinically available drugs (transarterial chemoembolization plus doxorubicin for intermediate HCCs or Sorafenib for advanced cases), whereas patients showing high miR-221 levels in the presence of a mutant TP53 isoform might be treated with an antagomiR-based strategy. Here, TP53 is linked to neoplasm.