MDM2 increased expression determined a downregulation of p53-signalling pathway, resulting in a decrease of p53-responsive miRNA clusters, miR-200b/a and 192/215, and in a consistent increase of their target gene ZEB1. Notably, the downregulation of miR-192 and miR-215 in HCC significantly associated with microvascular invasion (MVI), a marker of intrahepatic metastasis, whereas miR-192 and miR-200 levels inversely correlated with tumor size. The gene discussed is ZEB1; the disease is hepatocellular carcinoma.