To study the effects of VEGF antagonism in patients with CFH genetic variants and how these may alter complement cell-surface regulation, we studied RPE that carried the ARMD-associated CFH 402H polymorphism (ARMD RPE) and podocytes from an aHUS patient carrying a known CFH mutation (Arg1182Ser) (aHUS podocytes) (40). This evidence concerns the gene VEGFA and age-related macular degeneration.