Furthermore, i.v. administration of hMSCs, hMSCs with scrambled siRNA or rhTSG-6 all significantly attenuated the increase of serum MCP-1, a vital chemokine in the pathogenesis of pancreatitis (P < 0.01), while hMSCs with TSG-6 knockdown had no effect. The gene discussed is CCL2; the disease is pancreatitis.