As several studies have regarded MTDH as the potential biomarker which can indicate the metastasis and prognosis in malignancies, and as MTDH could miraculously induce breast cancer cells transferring to lung in mouse model, we carried out this comprehensive systematic review and meta-analysis based on published literature to thoroughly investigate the significance of MTDH in reproduction malignancies. Here, MTDH is linked to breast carcinoma.