TNF and neoplasm: Its gene, astrocyte elevated gene-1 (AEG-1), was first cloned in human fetal astrocytes as an inducible gene by human immunodeficiency virus 1 (HIV)-1 and tumor necrosis factor-α (TNF-α) in 20023, 4.Subsequently, clinical trial demonstrated that MTDH is a novel prognostic biomarker and high MTDH expression is associated with tumor progression and short overall survival (OS) time in breast cancer5.