MTDH and cancer: MTDH could mediate drug resistance in various cancers30 as suggested by Meng et al. For reproduction malignancies, it was reported that inhibition of MTDH increases cancer cells’ sensitivity to chemotherapy drugs, such as AZD6244, tumor necrosis factor-a-related apoptosis-inducing ligand (TRAIL) and HDAC inhibitor LBH58931, 32, 33.