In addition, gene-disease associations include β1-adrenergic receptor polymorphism linked to β-blocker response63, proteasome subunit a6, PSMA6, linked to myocardial infarctions in Japanese64 and methylthioadenylsine phosphorylase, MTAP, and cyclin-dependent kinase inhibitor 2B, CDKN2B, linked to heart disease in Chinese Han populations65. This evidence concerns the gene CDKN2B and heart disorder.