Hyperglycemia, hyperlipidemia, hyperinsulinemia17, 18, 53 and hyperuricemia62, 63, 64 of diabetics are common symptoms which enhance production of pro inflammatory markers such as CRP, IL6, TNFα, NF-κB17, 18, 53, 62, 64, reactive oxygen species (ROS) and reduce anti-inflammatory cytokine and adiponectin, which are involved in insulin resistance16, 65 and diabetes66. The gene discussed is TNF; the disease is diabetes mellitus.