Similarly, the analysis of data from two published studies31, 32 showed that SCN4B expression levels were downregulated in lung cancer compared with normal lung tissues (Supplementary Fig. 3a,b) and our immunohistochemical analyses in lung cancer tissue microarrays also identified a tendency for decreased protein expression in high-grade primary lung tumours and metastases (Supplementary Fig. 3c,d). The gene discussed is SCN4B; the disease is lung cancer.