Similarly, the analysis of data from two published studies31, 32 showed that SCN4B expression levels were downregulated in lung cancer compared with normal lung tissues (Supplementary Fig. 3a,b) and our immunohistochemical analyses in lung cancer tissue microarrays also identified a tendency for decreased protein expression in high-grade primary lung tumours and metastases (Supplementary Fig. 3c,d). This evidence concerns the gene SCN4B and lung carcinoma.