SCN4B and cancer: We however measured a decrease in the persistent INa current (Fig. 8e) and in INa persistent/peak ratio in oeSCN4B cells as compared with oeCTL (Fig. 8f) and a significant reduction of the focalized Matrigel degradation (Fig. 8g), suggesting that overexpression of SCN4B/β4 protein slightly reduced the persistent window current and its associated ECM proteolytic (mesenchymal) activity in cancer cells.